{"id":6494,"date":"2019-09-24T10:03:07","date_gmt":"2019-09-24T02:03:07","guid":{"rendered":"https:\/\/nhri.raise-up.com.tw\/hcc-model\/"},"modified":"2019-09-24T10:03:07","modified_gmt":"2019-09-24T02:03:07","slug":"hcc-model","status":"publish","type":"post","link":"https:\/\/ttic.nhri.edu.tw\/en\/hcc-model\/","title":{"rendered":"\u672c\u9662\u300c\u539f\u767c\u6027\u809d\u7d30\u80de\u764c\u5c0f\u9f20\u6a21\u5f0f\u300d\u516c\u958b\u5fb5\u6c42\u975e\u5c08\u5c6c\u6388\u6b0a\u6280\u8853\u79fb\u8f49\u5ee0\u5546(2019\/09\/24)"},"content":{"rendered":"\n

\u4e00\u3001\u4e3b\u65e8<\/h3>\n\n\n\n

\u672c\u9662\u300c\u539f\u767c\u6027\u809d\u7d30\u80de\u764c\u5c0f\u9f20\u6a21\u5f0f\u300d\u516c\u958b\u5fb5\u6c42\u975e\u5c08\u5c6c\u6388\u6b0a\u6280\u8853\u79fb\u8f49\u5ee0\u5546\u3002<\/p>\n\n\n\n

\u4e8c\u3001\u6388\u6b0a\u6280\u8853<\/h3>\n\n\n\n

(\u4e00)\u6280\u8853\u6458\u8981<\/strong><\/p>\n\n\n\n

\u3000\u3000\u672c\u6280\u8853\u5e73\u53f0\u5229\u7528\u9ad8\u58d3\u6ce8\u5c04\u6cd5\u53ca\u8df3\u8e8d\u5b50\u6280\u8853\uff0c\u4ee5sleeping beauty transposon system\uff0c\u5c07\u81f4\u764c\u57fa\u56e0\u9001\u5165\u514d\u75ab\u5065\u5168\u5c0f\u9f20\u809d\u81df\u7d30\u80de\u5167\u8a98\u767c\u809d\u7d30\u80de\u764c\uff0c\u85c9\u7531\u6b64\u6280\u8853\u6240\u8a98\u767c\u4e4b\u809d\u816b\u7624\u53ef\u8868\u73fe\u51b7\u5149\u53ca\u816b\u7624\u6297\u539f\uff0c\u56e0\u6b64\u53ef\u4ee5\u975e\u4fb5\u5165\u6027\u7684\u65b9\u5f0f\u89c0\u5bdf\u816b\u7624\u7684\u751f\u9577\u53ca\u5075\u6e2c\u5177\u816b\u7624\u6297\u539f\u7279\u7570\u6027\u4e4bT\u7d30\u80de\u53cd\u61c9\u3002\u6280\u8f49\u5167\u5bb9\u5305\u542b\u5982\u4e0b\uff1a<\/p>\n\n\n\n

  1. 2\u500bplasmids (pKT2\/CLP-AKT-LUC\u53capKT2\/CLP-AKT-OVA-HBc- HBs(Ags)-LUC)\u53ca\u5176\u76f8\u95dcDNA\u5e8f\u5217\u53camaps<\/li>
  2. \u6280\u8f49\u624b\u518a<\/li>
  3. \u6559\u80b2\u8a13\u7df4\uff1a\u63d0\u4f9b\u5169\u6b21\u51718\u5c0f\u6642\u6559\u80b2\u8a13\u7df4<\/li>
  4. \u6280\u8853\u8aee\u8a62\uff1a\u6bcf\u5e741\u6b21<\/li><\/ol>\n\n\n\n

    (\u4e8c)\u53ef\u80fd\u7684\u61c9\u7528\u7bc4\u570d\u8207\u5e02\u5834\u6f5b\u529b<\/strong><\/p>\n\n\n\n

    \u3000\u3000\u809d\u7d30\u80de\u764c(hepatocellular carcinoma, HCC)\u9ad8\u5c45\u764c\u75c7\u81f4\u6b7b\u7387\u7b2c2\u4f4d\uff0c\u76ee\u524d\u809d\u764c\u7684\u6cbb\u7642\u4ecd\u4ee5\u624b\u8853\u6cbb\u7642\u3001\u9152\u7cbe\u5c40\u90e8\u6ce8\u5c04\u3001\u96fb\u71d2\u53ca\u809d\u52d5\u8108\u5316\u5b78\u85e5\u7269\u6813\u585e\u6cbb\u7642(TACE)\u70ba\u4e3b\uff0c\u809d\u816b\u7624\u6cbb\u7642\u5f8c\u5fa9\u767c\u7387\u6975\u9ad8\uff0c\u540c\u6642\u5c0d\u6a19\u9776\u85e5\u7269\u53ca\u5316\u5b78\u85e5\u7269\u7684\u53cd\u61c9\u4e0d\u4f73\uff0c\u56e0\u6b64\u76ee\u524d\u809d\u764c\u7684\u514d\u75ab\u6cbb\u7642\u88ab\u5bc4\u4e88\u91cd\u671b\uff0c\u56e0\u800c\u6975\u9700\u80fd\u89c0\u5bdfHCC\u816b\u7624\u5fae\u74b0\u5883\uff0c\u53ca\u80fd\u7528\u65bc\u8a55\u4f30\u514d\u75ab\u6cbb\u7642\u6548\u679c\u7684\u81e8\u5e8a\u524d\u52d5\u7269\u6a21\u5f0f\u3002
    \u3000\u3000\u672c\u539f\u767c\u6027\u809d\u7d30\u80de\u764c\u5c0f\u9f20\u6a21\u5f0f\u8a98\u767c\u5f62\u6210\u4e4b\u816b\u7624\uff0c\u8868\u73fe\u51b7\u5149\u53ca\u816b\u7624\u6297\u539f\uff0c\u53ef\u7528\u65bc\u7814\u7a76\u5177\u816b\u7624\u7279\u7570\u6027\u4e4bT\u7d30\u80de\u53cd\u61c9\u53ca\u809d\u764c\u7d30\u80de\u8207\u514d\u75ab\u6291\u5236\u7d30\u80de\u7fa4\u4e4b\u4ea4\u4e92\u4f5c\u7528\uff0c\u540c\u6642\u6975\u9069\u5408\u505a\u70ba\u7814\u767c\u809d\u764c\u514d\u75ab\u7642\u6cd5\u53ca\u7d30\u80de\u6cbb\u7642\u4e4b\u81e8\u5e8a\u524d\u52d5\u7269\u6a21\u5f0f\uff0c\u4e5f\u53ef\u61c9\u7528\u65bc\u8a55\u4f30\u5c0f\u5206\u5b50\u85e5\u7269\u6cbb\u7642\u809d\u764c\u4e4b\u6548\u529b\u3002<\/p>\n\n\n\n

    (\u4e09)\u8207\u73fe\u6709\u6280\u8853\u6bd4\u8f03\uff0c\u6b64\u9805\u767c\u660e\u7684\u512a\u9ede<\/strong><\/p>\n\n\n\n

    \u3000\u3000\u76ee\u524d\u5be6\u9a57\u5ba4\u5e38\u7528\u4e4b\u809d\u7d30\u80de\u764c\u5c0f\u9f20\u6a21\u5f0f\u5305\u542b\u5316\u5b78\u8a98\u767c\u3001\u540c\u7a2e\u53ca\u7570\u7a2e\u79fb\u690d\u809d\u764c\u7d30\u80de\u682a\u3001\u57fa\u56e0\u8f49\u6b96\u6a21\u5f0f\u3002\u5316\u5b78\u8a98\u767c\u53ca\u57fa\u56e0\u8f49\u6b96\u9700\u8981\u9577\u6642\u9593\u624d\u80fd\u8a98\u767c\u816b\u7624\uff0c\u7570\u7a2e\u79fb\u690d\u6a21\u5f0f\u5247\u53ea\u80fd\u65bd\u6253\u65bc\u514d\u75ab\u7f3a\u640d\u9f20\uff0c\u800c\u540c\u7a2e\u79fb\u690d\u4e4b\u816b\u7624\u5fae\u74b0\u5883\u8207\u539f\u767c\u6027\u809d\u816b\u7624\u4e4b\u539f\u59cb\u6210\u56e0\u4e0d\u76e1\u76f8\u540c\u7684\u554f\u984c\u3002\u672c\u9805\u6280\u8853\u6709\u5982\u4e0b\u512a\u9ede\uff1a<\/p>\n\n\n\n

    1. \u4ee5\u9ad8\u58d3\u6ce8\u5c04\u6cd5\uff0c\u53ef\u76f4\u63a5\u5c07\u88f8\u9732\u8cea\u9ad4DNA\u9001\u5165\u809d\u7d44\u7e54\u4f7f\u8868\u9054\u76f8\u95dc\u86cb\u767d\u8cea\uff0c\u904e\u53bb\u88ab\u5ee3\u6cdb\u61c9\u7528\u65bc\u809d\u81df\u75c5\u6bd2\u611f\u67d3\u6216\u809d\u764c\u4e4b\u7814\u7a76\uff0c\u9ad8\u58d3\u6ce8\u5c04\u6cd5\u53ef\u5c07\u8f49\u6b96\u57fa\u56e0\u76f4\u63a5\u9001\u5165\u5404\u54c1\u7cfb\u5c0f\u9f20\u809d\u81df\uff0c\u7121\u9700\u900f\u904e\u7e41\u6b96\u6216\u88fd\u9020\u57fa\u56e0\u8f49\u6b96\u9f20\uff0c\u53ef\u964d\u4f4e\u7814\u7a76\u6210\u672c\u53ca\u6642\u9593\u3002<\/li>
    2. \u63a1\u7528\u9ad8\u58d3\u6ce8\u5c04\u6cd5\u53ca\u8df3\u8e8d\u5b50\u6280\u8853\uff0c\u4ee5sleeping beauty transposon system\uff0c\u5c07\u81f4\u764c\u57fa\u56e0Akt\u53caN-Ras\u9001\u5165\u514d\u75ab\u5065\u5168\u5c0f\u9f20\u809d\u81df\u7d30\u80de\u5167\u8a98\u767c\u809d\u7d30\u80de\u764c\uff0c\u6240\u8a98\u767c\u4e4b\u809d\u816b\u7624\u53ef\u8868\u73fe\u51b7\u5149\u53ca\u816b\u7624\u6297\u539f\uff0c\u56e0\u6b64\u53ef\u4ee5\u975e\u4fb5\u5165\u6027\u7684\u65b9\u5f0f\u89c0\u5bdf\u816b\u7624\u7684\u751f\u9577\u53ca\u5075\u6e2c\u5177\u816b\u7624\u6297\u539f\u7279\u7570\u6027\u4e4bT\u7d30\u80de\u53cd\u61c9\u3002<\/li>
    3. \u672c\u539f\u767c\u6027\u809d\u7d30\u80de\u764c\u5c0f\u9f20\u6a21\u5f0f\u4e4b\u816b\u7624\u5f62\u6210\u901f\u5ea6\uff0c\u5feb\u65bc\u5316\u5b78\u8a98\u767c\u53ca\u57fa\u56e0\u8f49\u6b96\u5c0f\u9f20\u4e4b\u816b\u7624\u751f\u6210\uff0c\u57282\u500b\u6708\u5167\u5373\u53ef\u8a98\u5c0e\u514d\u75ab\u5065\u5168\u5c0f\u9f20\u7522\u751f\u539f\u767c\u6027\u809d\u816b\u7624\uff0c\u7e2e\u77ed\u9032\u884c\u8a66\u9a57\u6240\u9700\u6642\u9593\u3002<\/li><\/ol>\n\n\n\n

      \u4e09\u3001\u5ee0\u5546\u8cc7\u683c<\/h3>\n\n\n\n

      \u9808\u5177\u5099\u4e0b\u5217\u689d\u4ef6\u8005\uff1a<\/p>\n\n\n\n

      1. \u4f9d\u6cd5\u767b\u8a18\u4e14\u7121\u9055\u6cd5\u7d00\u9304\u3002<\/li>
      2. \u5177\u6709\u76f8\u95dc\u6280\u8853\u958b\u767c\u7d93\u9a57\u8207\u80fd\u529b\u8005\u4f73\u3002<\/li>
      3. \u9858\u610f\u9577\u671f\u6295\u5165\u7814\u767c\u8cc7\u91d1\u8005\u4f73\u3002<\/li><\/ol>\n\n\n\n

        \u56db\u3001\u5be9\u67e5<\/h3>\n\n\n\n

        \u7b26\u5408\u4e0a\u8ff0\u8cc7\u683c\u4e14\u6709\u610f\u9858\u8005\uff0c\u8acb\u586b\u59a5\u300c\u6280\u8853\u79fb\u8f49\u4f01\u5283\u66f8\u300d(\u683c\u5f0f\u5982\u9644\u4ef6\u4e8c)\u4e4b\u76f8\u95dc\u8cc7\u6599\u3014\u5167\u542b\u516c\u53f8\u7c21\u4ecb\u53ca\u53ef\u95e1\u660e\u4e0a\u8ff0\u689d\u4ef6\u4e4b\u8cc7\u6599\u3015\uff0c\u4e26\u6a19\u660e\u5ee0\u5546\u540d\u7a31\u548c\u5730\u5740\u3001\u806f\u7d61\u4eba\u96fb\u8a71\u8207\u96fb\u5b50\u90f5\u4ef6\u7b49\u8cc7\u6599\uff0c\u65bc\u6c11\u570b 108 \u5e7410\u670823\u65e5 (\u661f\u671f\u4e09) \u524d\u4ee5\u90f5\u5bc4\u6b63\u672c\u4e26\u642d\u914d\u50b3\u771f\u6216\u96fb\u5b50\u90f5\u4ef6\u65b9\u5f0f\uff0c\u9001\u9054\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\u6280\u8f49\u53ca\u80b2\u6210\u4e2d\u5fc3 \u6881\u83ef\u8ed2\u5148\u751f\u6536\uff08\u5730\u5740\uff1a\u300c\u82d7\u6817\u7e2335053\u7af9\u5357\u93ae\u79d1\u7814\u8def35\u865f\u884c\u653f\u5927\u6a133\u6a13 \u6280\u8f49\u53ca\u80b2\u6210\u4e2d\u5fc3\u300d\uff0cFAX: (037)583-667\uff0cE-mail\uff1ahuahsuan@nhri.org.tw\uff09\u3002\u65bc\u5fc5\u8981\u6642\uff0c\u672c\u9662\u5f97\u8981\u6c42\u5ee0\u5546\u6d3e\u54e1\u8aaa\u660e\uff0c\u5be9\u67e5\u59d4\u54e1\u6703\u5c07\u5c31\u5ee0\u5546\u63d0\u4f9b\u8cc7\u6599\u9032\u884c\u8a55\u6bd4\u3002<\/p>\n\n\n\n

        \u9644\u6a94
        \u9644\u4ef6\u4e00\uff1a\u6280\u8f49\u516c\u544a\u96fb\u5b50\u6a94\uff1a\u300c\u539f\u767c\u6027\u809d\u7d30\u80de\u764c\u5c0f\u9f20\u6a21\u5f0f\u300d\u5fb5\u6c42\u6280\u8853\u79fb\u8f49\u5ee0\u5546<\/a>
        \u9644\u4ef6\u4e8c\uff1a        \u6280\u8853\u79fb\u8f49\u4f01\u5283\u66f8<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

        \u4e00\u3001\u4e3b\u65e8 \u672c\u9662\u300c\u539f\u767c\u6027\u809d\u7d30\u80de\u764c\u5c0f\u9f20\u6a21\u5f0f\u300d\u516c\u958b\u5fb5\u6c42\u975e\u5c08\u5c6c\u6388\u6b0a\u6280\u8853\u79fb\u8f49\u5ee0\u5546\u3002 \u4e8c\u3001\u6388\u6b0a\u6280\u8853 (\u4e00)\u6280\u8853\u6458\u8981 \u3000\u3000\u672c\u6280\u8853\u5e73\u53f0\u5229\u7528\u9ad8\u58d3\u6ce8\u5c04\u6cd5\u53ca\u8df3\u8e8d\u5b50\u6280\u8853\uff0c\u4ee5sleeping beauty transposon system\uff0c\u5c07\u81f4\u764c\u57fa\u56e0\u9001\u5165\u514d\u75ab\u5065\u5168\u5c0f\u9f20\u809d\u81df\u7d30\u80de\u5167\u8a98\u767c\u809d\u7d30\u80de\u764c\uff0c\u85c9\u7531\u6b64\u6280\u8853\u6240\u8a98\u767c\u4e4b\u809d\u816b\u7624\u53ef\u8868\u73fe\u51b7\u5149\u53ca\u816b\u7624\u6297\u539f\uff0c\u56e0\u6b64\u53ef\u4ee5\u975e\u4fb5\u5165\u6027\u7684\u65b9\u5f0f\u89c0\u5bdf\u816b\u7624\u7684\u751f\u9577\u53ca\u5075\u6e2c\u5177\u816b\u7624\u6297\u539f\u7279\u7570\u6027\u4e4bT\u7d30\u80de\u53cd\u61c9\u3002\u6280\u8f49\u5167\u5bb9\u5305\u542b\u5982\u4e0b\uff1a 2\u500bplasmids (pKT2\/CLP-AKT-LUC\u53capKT2\/CLP-AKT-OVA-HBc- HBs(Ags)-LUC)\u53ca\u5176\u76f8\u95dcDNA\u5e8f\u5217\u53camaps \u6280\u8f49\u624b\u518a \u6559\u80b2\u8a13\u7df4\uff1a\u63d0\u4f9b\u5169\u6b21\u51718\u5c0f\u6642\u6559\u80b2\u8a13\u7df4 \u6280\u8853\u8aee\u8a62\uff1a\u6bcf\u5e741\u6b21 (\u4e8c)\u53ef\u80fd\u7684\u61c9\u7528\u7bc4\u570d\u8207\u5e02\u5834\u6f5b\u529b \u3000\u3000\u809d\u7d30\u80de\u764c(hepatocellular carcinoma, 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